open access

Vol 67, No 10 (2009)
Other
Published online: 2009-10-29
Submitted: 2012-12-28
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Original article
Association between paraoxonase activity and late saphenous vein graft occlusion in patients with coronary artery bypass grafting

Goksel Cagirci, Serkan Cay, Ozlem Karakurt, Nuray Yazihan, Cengiz Aydin, Sadik Acikel, Mehmet Dogan, Harun Kilic, Serkan Topaloglu, Dursun Aras, Ramazan Akdemir
Kardiol Pol 2009;67(10):1063-1068.

open access

Vol 67, No 10 (2009)
Other
Published online: 2009-10-29
Submitted: 2012-12-28

Abstract


Background: Coronary vein graft disease is an important contributor to the morbidity after coronary artery bypass grafting (CABG). Late occlusion of the graft is a serious complication that limits the use of the saphenous vein as a coronary bypass conduit. It is frequently encountered in old, degenerated vein grafts with advanced atherosclerotic plaque formation. Paraoxonase-1 (PON-1) is an HDL-bound enzyme which has anti-atherogenic properties and protects LDL cholesterol from oxidative modification.
Aim: To examine the association between PON-1 activity and late saphenous vein graft occlusion.
Methods: Thirty-eight patients who had at least one occluded saphenous vein graft (group 1; 12 females, 26 males) and 41 patients who had a patent saphenous vein graft (group 2; 7 females, 34 males) were enrolled in this study. Paraoxonase activity was measured spectrophotometrically.
Results: The mean PON-1 activity in group 1 was significantly lower than in group 2 (74.1 ± 52.1 vs. 114.4 ± 90.9 U/l, p = 0.02). The mean platelet volume was significantly higher in group 1 than group 2 (8.8 ± 1.6 vs. 8.2 ± 1.1 fl, p = 0.04). Multiple logistic regression analysis showed that only PON-1 activity (beta = 0.011, p = 0.042) was an independent predictor of late occlusion of a saphenous vein graft.
Conclusions: Our results show that PON-1 activity is lower in patients with late saphenous vein graft occlusion. Reduced PON-1 activity may lead to acceleration of saphenous vein graft occlusion.

Abstract


Background: Coronary vein graft disease is an important contributor to the morbidity after coronary artery bypass grafting (CABG). Late occlusion of the graft is a serious complication that limits the use of the saphenous vein as a coronary bypass conduit. It is frequently encountered in old, degenerated vein grafts with advanced atherosclerotic plaque formation. Paraoxonase-1 (PON-1) is an HDL-bound enzyme which has anti-atherogenic properties and protects LDL cholesterol from oxidative modification.
Aim: To examine the association between PON-1 activity and late saphenous vein graft occlusion.
Methods: Thirty-eight patients who had at least one occluded saphenous vein graft (group 1; 12 females, 26 males) and 41 patients who had a patent saphenous vein graft (group 2; 7 females, 34 males) were enrolled in this study. Paraoxonase activity was measured spectrophotometrically.
Results: The mean PON-1 activity in group 1 was significantly lower than in group 2 (74.1 ± 52.1 vs. 114.4 ± 90.9 U/l, p = 0.02). The mean platelet volume was significantly higher in group 1 than group 2 (8.8 ± 1.6 vs. 8.2 ± 1.1 fl, p = 0.04). Multiple logistic regression analysis showed that only PON-1 activity (beta = 0.011, p = 0.042) was an independent predictor of late occlusion of a saphenous vein graft.
Conclusions: Our results show that PON-1 activity is lower in patients with late saphenous vein graft occlusion. Reduced PON-1 activity may lead to acceleration of saphenous vein graft occlusion.
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Keywords

paraoxonase; saphenous vein graft

About this article
Title

Original article
Association between paraoxonase activity and late saphenous vein graft occlusion in patients with coronary artery bypass grafting

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 67, No 10 (2009)

Pages

1063-1068

Published online

2009-10-29

Bibliographic record

Kardiol Pol 2009;67(10):1063-1068.

Keywords

paraoxonase
saphenous vein graft

Authors

Goksel Cagirci
Serkan Cay
Ozlem Karakurt
Nuray Yazihan
Cengiz Aydin
Sadik Acikel
Mehmet Dogan
Harun Kilic
Serkan Topaloglu
Dursun Aras
Ramazan Akdemir

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