open access

Vol 67, No 6 (2009)
Other
Published online: 2009-06-24
Submitted: 2012-12-28
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Original article
Atorvastatin reduces sympathetic activity and increases baroreceptor reflex sensitivity in patients with hypercholesterolaemia and systemic arterial hypertension

Maciej Siński, Jacek Lewandowski, Agnieszka Ciarka, Joanna Bidiuk, Piotr Abramczyk, Anna Dobosiewicz, Zbigniew Gaciong
Kardiol Pol 2009;67(6):613-620.

open access

Vol 67, No 6 (2009)
Other
Published online: 2009-06-24
Submitted: 2012-12-28

Abstract

Background: Increased sympathetic activity might be related to pathogenesis of hypertension as well as to end organ damage. Animal studies suggest that statins decrease sympathetic activity and increase baroreceptor reflex sensitivity (BRS).
Aim: To examine whether atorvastatin decreases muscle sympathetic nerve activity (MSNA) and BRS in hypercholesterolaemic and hypertensive patients.
Methods: Ten patients with essential hypertension and untreated hypercholesterolaemia (aged 43 ± 12 years) and eight healthy subjects (aged 37 ± 7 years) were enrolled in the study. In both groups the recordings of microneurography, ECG, blood pressure and BRS were performed twice, before and after 8 weeks during which the patients (but not controls) were treated with atorvastatin.
Results: Compared with controls, the patients had higher MSNA values (36.0 ± 6.6 vs. 29.8 ± 3.7 bursts/minute), mean BP levels (145.1 ± 10 vs. 124.1 ± 11.1 mmHg) and total cholesterol concentration (252.6 ± 22.6 vs. 179.8 ± 20.7 mg/dl) baseline values. Statin therapy resulted in a decrease of total cholesterol (252.6 ± 22.0 vs. 173.8 ± 26.2 mg/dl, p < 0.05) and MSNA (36.0 ± 6.6 vs. 28.6 ± 4.8 bursts/min, p < 0.05), whereas BRS values were increased (12.6 ± 5.6 vs. 18.1 ± 5.9 ms/mmHg, p < 0.05). Post-treatment BRS was inversely related to post-treatment MSNA (r = –0.73, p < 0.05). In the controls there were no changes in MSNA (29.8 ± 3.7 vs. 28.9 ± 2.9 bursts/min), BRS (11.9 ± 5.0 vs. 13.1 ± 4.8 ms/mmHg), total cholesterol, BP and heart rate between the first and the second measurement.
Conclusion: Atorvastatin reduces MSNA and increases BRS in hypertensive and hypercholesterolaemic patients. Decrease in sympathetic activity may be the result of improvement of baroreceptor function by atorvastatin.

Abstract

Background: Increased sympathetic activity might be related to pathogenesis of hypertension as well as to end organ damage. Animal studies suggest that statins decrease sympathetic activity and increase baroreceptor reflex sensitivity (BRS).
Aim: To examine whether atorvastatin decreases muscle sympathetic nerve activity (MSNA) and BRS in hypercholesterolaemic and hypertensive patients.
Methods: Ten patients with essential hypertension and untreated hypercholesterolaemia (aged 43 ± 12 years) and eight healthy subjects (aged 37 ± 7 years) were enrolled in the study. In both groups the recordings of microneurography, ECG, blood pressure and BRS were performed twice, before and after 8 weeks during which the patients (but not controls) were treated with atorvastatin.
Results: Compared with controls, the patients had higher MSNA values (36.0 ± 6.6 vs. 29.8 ± 3.7 bursts/minute), mean BP levels (145.1 ± 10 vs. 124.1 ± 11.1 mmHg) and total cholesterol concentration (252.6 ± 22.6 vs. 179.8 ± 20.7 mg/dl) baseline values. Statin therapy resulted in a decrease of total cholesterol (252.6 ± 22.0 vs. 173.8 ± 26.2 mg/dl, p < 0.05) and MSNA (36.0 ± 6.6 vs. 28.6 ± 4.8 bursts/min, p < 0.05), whereas BRS values were increased (12.6 ± 5.6 vs. 18.1 ± 5.9 ms/mmHg, p < 0.05). Post-treatment BRS was inversely related to post-treatment MSNA (r = –0.73, p < 0.05). In the controls there were no changes in MSNA (29.8 ± 3.7 vs. 28.9 ± 2.9 bursts/min), BRS (11.9 ± 5.0 vs. 13.1 ± 4.8 ms/mmHg), total cholesterol, BP and heart rate between the first and the second measurement.
Conclusion: Atorvastatin reduces MSNA and increases BRS in hypertensive and hypercholesterolaemic patients. Decrease in sympathetic activity may be the result of improvement of baroreceptor function by atorvastatin.
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Keywords

sympathetic system; statins; hypercholesterolaemia; hypertension; baroreflex sensitivity

About this article
Title

Original article
Atorvastatin reduces sympathetic activity and increases baroreceptor reflex sensitivity in patients with hypercholesterolaemia and systemic arterial hypertension

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 67, No 6 (2009)

Pages

613-620

Published online

2009-06-24

Bibliographic record

Kardiol Pol 2009;67(6):613-620.

Keywords

sympathetic system
statins
hypercholesterolaemia
hypertension
baroreflex sensitivity

Authors

Maciej Siński
Jacek Lewandowski
Agnieszka Ciarka
Joanna Bidiuk
Piotr Abramczyk
Anna Dobosiewicz
Zbigniew Gaciong

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