open access

Vol 70, No 9 (2012)
Original articles
Published online: 2012-09-20
Submitted: 2012-12-28
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CD36 gene is associated with thickness of atheromatous plaque and ankle−brachial index in patients with early coronary artery disease

Monika Ewa Rać, Krzysztof Safranow, Michał Rać, Grzegorz Kurzawski, Andrzej Krzystolik, Dagmara Sagasz−Tysiewicz, Katarzyna Jakubowska, Wojciech Poncyljusz, Dariusz Chlubek
Kardiol Pol 2012;70(9):918-923.

open access

Vol 70, No 9 (2012)
Original articles
Published online: 2012-09-20
Submitted: 2012-12-28

Abstract

Background: CD36 is a multifunctional molecule engaged in the removal of oxidised LDL from plasma. It is unclear whether mutation of the CD36 gene protects against, or increases, the risk of hypercholesterolaemia, atherosclerosis and its complications.
Aim: To search for associations between the CD36 gene polymorphisms and radiological markers of atherosclerosis progress in Caucasian patients with coronary artery disease (CAD) diagnosed at a young age.
Methods: The study group comprised 70 patients with early CAD. Doppler ultrasound of carotid and peripheral arteries was carried out and genomic DNA was isolated from each patient.
Results: We found two single nucleotide substitutions in introns (IVS3-6 T/C – rs3173798 and IVS4-10 G/A – rs3211892) and two synonymous polymorphisms in exon 6 (G573A – rs5956 and A591T). The allele frequencies were: 10.7% for the IVS3-6C, 3.6% for the IVS4-10A, 3.6% for the 573A, and 2.1% for the 591T. The 573A allele of CD36 rs5956 polymorphism is associated with low thickness of atheromatous plaque. The 591T allele is associated with lower ankle–brachial index.
Conclusions: The 573A allele has a protective effect against atherosclerosis development and the 591T allele is a cardiovascular risk factor. Assessment of their functional implications requires further research.

Abstract

Background: CD36 is a multifunctional molecule engaged in the removal of oxidised LDL from plasma. It is unclear whether mutation of the CD36 gene protects against, or increases, the risk of hypercholesterolaemia, atherosclerosis and its complications.
Aim: To search for associations between the CD36 gene polymorphisms and radiological markers of atherosclerosis progress in Caucasian patients with coronary artery disease (CAD) diagnosed at a young age.
Methods: The study group comprised 70 patients with early CAD. Doppler ultrasound of carotid and peripheral arteries was carried out and genomic DNA was isolated from each patient.
Results: We found two single nucleotide substitutions in introns (IVS3-6 T/C – rs3173798 and IVS4-10 G/A – rs3211892) and two synonymous polymorphisms in exon 6 (G573A – rs5956 and A591T). The allele frequencies were: 10.7% for the IVS3-6C, 3.6% for the IVS4-10A, 3.6% for the 573A, and 2.1% for the 591T. The 573A allele of CD36 rs5956 polymorphism is associated with low thickness of atheromatous plaque. The 591T allele is associated with lower ankle–brachial index.
Conclusions: The 573A allele has a protective effect against atherosclerosis development and the 591T allele is a cardiovascular risk factor. Assessment of their functional implications requires further research.
Get Citation

Keywords

CD36 gene; genetic risk factors; atheromatous plaque; ankle–brachial index

About this article
Title

CD36 gene is associated with thickness of atheromatous plaque and ankle−brachial index in patients with early coronary artery disease

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 70, No 9 (2012)

Pages

918-923

Published online

2012-09-20

Bibliographic record

Kardiol Pol 2012;70(9):918-923.

Keywords

CD36 gene
genetic risk factors
atheromatous plaque
ankle–brachial index

Authors

Monika Ewa Rać
Krzysztof Safranow
Michał Rać
Grzegorz Kurzawski
Andrzej Krzystolik
Dagmara Sagasz−Tysiewicz
Katarzyna Jakubowska
Wojciech Poncyljusz
Dariusz Chlubek

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