open access

Vol 67, No 9 (2009)
Other
Published online: 2009-10-12
Submitted: 2012-12-28
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Original article
The effect of an evening dose of a long-acting beta-blocker on the autonomic tone in patients with congestive heart failure

Ryszard Targoński, Janusz Sadowski
Kardiol Pol 2009;67(9):963-970.

open access

Vol 67, No 9 (2009)
Other
Published online: 2009-10-12
Submitted: 2012-12-28

Abstract

Background: Heart rate variability (HRV) indices are accepted markers of cardiac autonomic activity and have been used as indicators of beta-blockade effects in congestive heart failure (CHF) patients. In view of the high frequency of sudden cardiac death in the morning, there is a question whether the evening beta-blocker administration would be more efficient than a morning dose.
Aim: To compare HRV indices after morning or evening long-acting beta-blocker administration.
Methods: The study group consisted of 52 CHF patients (NYHA class II/III) in sinus rhythm. Time domain (TD) and frequency domain (FD) HRV analyses were performed for daytime, nighttime and a 24-hour period: first after the morning bisoprolol administration, and then after the same evening dose.
Results: After the evening dose the mean heart rate was significantly lower (p = 0.01), nighttime normal R-R intervals were significantly prolonged (p = 0.008) and the low frequency (LF)/high frequency (HF) ratio was significantly lower for: 24 h (p = 0.0002); daytime (p = 0.003) and nighttime (p = 0.008) with higher HF values in the 24-hour period (p = 0.0007) and in the daytime interval (p = 0.006).
Conclusion: An evening dose of a beta-blocker is more effective than a morning dose in reversing adverse changes in the autonomic nervous system activity in CHF patients.

Abstract

Background: Heart rate variability (HRV) indices are accepted markers of cardiac autonomic activity and have been used as indicators of beta-blockade effects in congestive heart failure (CHF) patients. In view of the high frequency of sudden cardiac death in the morning, there is a question whether the evening beta-blocker administration would be more efficient than a morning dose.
Aim: To compare HRV indices after morning or evening long-acting beta-blocker administration.
Methods: The study group consisted of 52 CHF patients (NYHA class II/III) in sinus rhythm. Time domain (TD) and frequency domain (FD) HRV analyses were performed for daytime, nighttime and a 24-hour period: first after the morning bisoprolol administration, and then after the same evening dose.
Results: After the evening dose the mean heart rate was significantly lower (p = 0.01), nighttime normal R-R intervals were significantly prolonged (p = 0.008) and the low frequency (LF)/high frequency (HF) ratio was significantly lower for: 24 h (p = 0.0002); daytime (p = 0.003) and nighttime (p = 0.008) with higher HF values in the 24-hour period (p = 0.0007) and in the daytime interval (p = 0.006).
Conclusion: An evening dose of a beta-blocker is more effective than a morning dose in reversing adverse changes in the autonomic nervous system activity in CHF patients.
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Keywords

heart failure; heart rate; beta blockade; autonomic nervous system

About this article
Title

Original article
The effect of an evening dose of a long-acting beta-blocker on the autonomic tone in patients with congestive heart failure

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 67, No 9 (2009)

Pages

963-970

Published online

2009-10-12

Bibliographic record

Kardiol Pol 2009;67(9):963-970.

Keywords

heart failure
heart rate
beta blockade
autonomic nervous system

Authors

Ryszard Targoński
Janusz Sadowski

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